Wilms Tumor Ppt New [repack] -

This report provides a structured overview of Wilms tumor (nephroblastoma) based on 2025–2026 clinical guidelines and research. It is designed for use as a detailed reference for a medical presentation. 🧬 Overview & Epidemiology

Most common pediatric renal cancer (95% of childhood kidney cases).

Incidence: Approximately 650 new cases yearly in the U.S.; 1 in 10,000 children globally.

Median Age: 3.5 years; 90% of cases are diagnosed before age 7. wilms tumor ppt new

Laterality: 90% are unilateral; 10% are bilateral or multifocal (suggesting germline mutations). 🩺 Clinical Presentation

Abdominal Mass: Usually painless, firm, smooth, and non-tender (83% of cases). Abdominal Pain: Occurs in ~37% of patients.

Hypertension: Present in 20–25% due to increased renin activity. Hematuria: Microscopic or gross blood in urine (21–25%). Constitutional Symptoms: Fever, anorexia, and vomiting. Genetic Predisposition & Syndromes This report provides a structured overview of Wilms

Approximately 10–15% of cases are associated with a predisposition syndrome. Genetic Marker WAGR Wilms, Aniridia, Genitourinary anomalies, Retardation 11p13 deletion (WT1) Denys-Drash Nephropathy, Wilms, ambiguous genitalia WT1 mutation Beckwith-Wiedemann Overgrowth, macroglossia, omphalocele 11p15 (WT2/IGF2) Perlman Fetal gigantism, nephroblastomatosis 🔬 Pathology & Staging Histology Types

Favorable Histology (FH): Standard triphasic pattern (blastemal, epithelial, stromal cells).

Anaplastic Histology: Presence of enlarged nuclei and hyperchromasia; associated with chemoresistance and poorer prognosis. Staging (COG/NWTS System) How to Create an Effective PowerPoint on Wilms

How to Create an Effective PowerPoint on Wilms Tumor (Nephroblastoma)

A well-designed PowerPoint presentation on Wilms Tumor can simplify a complex pediatric oncology topic. Whether you are preparing for a medical school seminar, a residency teaching round, or a parent education session, the key is balancing pathology, clinical management, and visual clarity. Below is a blueprint for structuring your PPT, along with essential content to include.

Slide 7: Diagnostic Workup

• Imaging:
  • Abdominal Ultrasound: First-line test to confirm cystic vs. solid mass and assess IVC/renal vein thrombosis.
  • CT Abdomen/Pelvis: Defines extent, contralateral kidney check, and lymph node status.
  • Chest CT: Essential for staging lung metastases (Stage IV).
• Labs:
  • CBC, LFTs, Renal function (BMP).
  • Urinalysis (hematuria).
• Biopsy:
  • Controversial: In the US/COG protocols, upfront biopsy is generally avoided (risk of spillage/upstaging) unless tumor is unresectable or bilateral. Diagnosis is confirmed at surgery.

Slide 10: Take-Home Pearls

• Always palpate an abdominal mass gently (rupture risk → upstaging).
• Wilms Tumor is highly chemosensitive – survival is excellent with proper risk stratification.
• Do not biopsy before referral to a pediatric oncology center unless absolutely necessary.

Slide 2: Introduction & Epidemiology

• Definition: Most common primary malignant renal tumor of childhood.
• Origin: Embryonal renal stem cells (metanephric blastema).
• Epidemiology:
  • Incidence: ~1 in 10,000 children.
  • Peak Age: 3–4 years old (rare in neonates and adults).
  • Slight female predominance.
• Key Stat: Accounts for ~6% of all childhood cancers.

Slide 5: Pathology (The "Triphasic" Appearance)

• Gross Appearance: Large, bulky mass; usually solitary; well-circumscribed with a pseudocapsule. Cut surface is fleshy, gray-white, and often necrotic/hemorrhagic.
• Microscopic Features (Triphasic Histology):
  1. Blastema: Small blue round cells (immature, malignant component).
  2. Epithelium: Immature glomeruli and tubules.
  3. Stroma: Fibrocytic or myxoid spindle cells.
• Anaplasia (Critical Concept):
  • Defined by large, hyperchromatic nuclei and multipolar mitotic figures.
  • Focal Anaplasia: Better prognosis.
  • Diffuse Anaplasia: Poor prognosis, resistant to chemotherapy.

Wilms Tumor PPT New: A Modern Guide to Presentation, Diagnosis, and Treatment Updates

Keywords: Wilms tumor ppt new, nephroblastoma slides, pediatric renal cancer, COG protocol, Umbrella protocol, pediatric oncology lecture

Slide 5: Pathology – The 2025 WHO Classification Update

Add this slide to your PPT – crucial for “new”.

The 5th edition (WHO 2022, implemented globally by 2025) introduces:

1. Favorable histology – triphasic; excellent prognosis.
2. Diffuse anaplasia – large, hyperchromatic nuclei, atypical mitoses; high risk.
3. Focal anaplasia – intermediate.
4. New entity: Cystic partially differentiated nephroblastoma (benign behavior; no chemo).
5. New: Blastemal-predominant subtype after SIOP chemo – poor prognosis regardless of stage → upgrade to high-risk therapy.

Microscopy images in PPT are mandatory here.