S Gastrointestinal And Liver Disease 12th Edition [patched] May 2026

Sleisenger and Fordtran’s Gastrointestinal and Liver Disease, 12th Edition (2020)

Key Points Boxes

Each major section begins with a "Key Points" summary—perfect for rapid clinical decision-making during a busy clinic day. For example, the chapter on acute pancreatitis now opens with a bulleted list of the revised Atlanta classification, indications for early ERCP, and fluid resuscitation targets (goal-directed vs. aggressive).

Part V: Colon & Anorectum

15. Irritable Bowel Syndrome (IBS) (major rewrite: Rome V criteria preview, low-FODMAP, rifaximin)
16. Inflammatory Bowel Disease (IBD) – two chapters:
    • 16A: UC & Crohn’s – Medical Therapy (new: ozanimod, upadacitinib, risankizumab)
    • 16B: IBD – Surgical & Endoscopic Management (new: strictureplasty, J-pouch salvage)
17. Colorectal Cancer Screening (new: mt-sDNA, blood-based assays, AI-assisted colonoscopy)

Part VII: Liver

21. Approach to the Patient with Jaundice & Abnormal LFTs (new: novel biomarkers)
22. MASLD (formerly NAFLD) – complete rewrite (new: resmetirom, GLP-1 agonists)
23. Alcoholic Liver Disease (updated: early liver transplant, pentoxifylline role)
24. Viral Hepatitis:
    • 24A: Hepatitis B (new: RNAi therapies – JNJ-3989, bepirovirsen)
    • 24B: Hepatitis C (updated: pangenotypic DAA retreatment strategies)
    • 24C: Hepatitis E (new: solid organ transplant considerations)
25. Autoimmune Liver Disease (AIH, PBC, PSC) – new: obeticholic acid, fibrates for PBC
26. Vascular Liver Disorders (Budd-Chiari, PVT, TIPS updates)
27. Hepatocellular Carcinoma (new: atezolizumab-bevacizumab, durvalumab-tremelimumab)
28. Acute Liver Failure & Critical Care Hepatology
29. Liver Transplantation (updated: machine perfusion, frailty assessment, HCV donor to HCV- recipient)

High-Quality Imaging and Video Support

The text is integrated with an online companion site (access code included with purchase) featuring: s gastrointestinal and liver disease 12th edition

• Over 1,500 figures, many in vibrant color.
• Video clips of endoscopic procedures, including polypectomy, variceal banding, and peroral cholangioscopy.
• Histopathology slides correlating endoscopic findings with microscopic disease.

Introduction

In the realm of medical literature, few titles command the respect and authority of Sleisenger and Fordtran. For decades, it has been universally recognized as the "Bible" of gastroenterology. The release of the 12th Edition continues this legacy, offering a comprehensive update to the definitive reference for gastroenterologists, hepatologists, internists, and surgeons. As the field of GI medicine evolves rapidly with new biologics, endoscopic techniques, and genetic discoveries, this text serves as the essential bridge between foundational science and modern clinical practice. Irritable Bowel Syndrome (IBS) (major rewrite: Rome V

Key Editors

The 12th edition is helmed by a prestigious editorial team: 16A: UC & Crohn’s – Medical Therapy (new:

• Mark Feldman, MD (Chair, Department of Internal Medicine, Texas Health Presbyterian Hospital of Dallas)
• Lawrence S. Friedman, MD (Professor of Medicine, Harvard Medical School)
• Lawrence J. Brandt, MD (Emeritus Professor of Medicine and Surgery, Albert Einstein College of Medicine)