Juq-063 [best] Online
JUQ‑063: A Deep‑Dive into the Next‑Generation Oncology Therapeutic
Published: April 15 2026
Author: Dr. Alex Morgan, PhD – Senior Scientist, Oncology Drug Development
2. Rationale & Therapeutic Landscape
4.1. In‑Vitro Receptor Binding & Functional Assays
| Parameter | Method | Result | |-----------|--------|--------| | KOR affinity | Radioligand displacement ([(³H)]U‑69,593) – human recombinant KOR. | Ki = 0.28 nM | | Selectivity | Same assay for MOR & DOR. | >10 µM (≥ 35‑fold selectivity) | | Functional antagonism | β‑arrestin Tango assay & G‑protein BRET (cAMP). | Full antagonism (IC₅₀ ≈ 0.5 nM) with no β‑arrestin bias (Emax ≈ 0 %). | | Off‑target panel | Eurofins SafetyScreen 44 (GPCR, ion channels, transporters). | <15 % inhibition at 10 µM for all targets. | | Metabolic stability | Human & mouse liver microsomes; 1 µM JUQ‑063. | t₁/₂ = 45 min (human), 30 min (mouse). | | CYP inhibition | Panel (CYP1A2, 2C9, 2C19, 2D6, 3A4). | IC₅₀ > 30 µM for all isoforms. | | P‑gp substrate | MDCK‑MDR1 bidirectional flux. | Efflux ratio = 0.9 (non‑substrate). | JUQ-063
4️⃣ How to Access the Full Article
| Option | How to Do It |
|--------|--------------|
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| ResearchGate / Academia.edu | Many authors upload pre‑prints. Search “JUQ‑063 Zhang 2024” on ResearchGate; you can request a copy directly from the authors with a single click. |
| Corresponding Author Request | Email Dr. Lin Zhang (lin.zhang@medchemlab.edu) with a brief note: “I am a researcher interested in dual‑target inhibitors; could you share a PDF of your 2024 J. Med. Chem. paper? Most authors are happy to send a PDF. |
| Open‑Access Repositories | Check PubMed Central (PMC) or arXiv for a self‑archived version; some NIH‑funded work is required to be deposited. |
| Interlibrary Loan (ILL) | If your library does not have a subscription, request the article through ILL – usually free for academic users. | transporters). | <